The result also represented a perfect response to the home side’s disappointing opening loss when they were beaten by the Warriors, and the weather, on the DLS Method over the weekend.
Mark Boucher’s side were excellent throughout on the East Rand, and after winning the toss and bowling, they chipped away regularly to keep the Cobras in check.
Shaun von Berg (1/18) and the double-handed Gregory Mahlokwana (1/19) were excellent, while Eldred Hawken (1/39) picked up the key wicket of Hashim Amla (2) early on.
There were 20s from Janneman Malan (22), Simon Khomari (20) and Vernon Philander (22 not out), while Kyle Verreynne struck an impressive 44 off 38 before taking a blow from a Junior Dala delivery that forced him to retire hurt.
Rory Kleinveldt smashed two sixes in the final over that gave the away side a seemingly competitive 150 for five.
But that total proved no match for the Titans as they eased to victory and second place on the standings.